Detection of herpes simplex viruses in the oral lesions of patients with pemphigus vulgaris: Is it diagnostic or predictive of disease severity?

Background Some studies emphasise the relationship between herpes simplex virus (HSV) and pemphigus. Although possible role of HSV in pathogenesis pemphigus severity disease is obscure, we aimed to evaluate presence viruses (HSV 1/2) oral lesions patients with vulgaris also assess its association types lesions. Methods A retrospective study was conducted on collected data form collecting paraffin blocks, slides, relevant pathology reports referring patients' medical records. questionnaire containing details degree skin, scalp, mucosal involvement (Pemphigus Disease Area Index (PDAI)) fulfiled. The immunoassay result check anti-desmoglein 3 1 antibodies (using ELISA technique). Results In this study, 52 (case) not related (control) were evaluated. HSV1 detected 13.5% 1.9% control group (p = 0.0598). There no positive cases HSV2 either group. significant positivity site 1.00) or 0.28). However, found a strong correlation PDAI score titre AntiDsg3 antibody (r 0.487, p 0.001) AntiDsg1 0.309, 0.026). Conclusion This demonstrated prevalence lesions, acyclovir therapy may play managing these patients. HSV's cannot be clearly determined.